Cyp27b1 - cytochrome P450, family 27, subfamily b, polypeptide 1 Gene

Also Known as Vdr; Cp2b; Cyp1; Pddr; Vdd1; Vddr; Cyp40; VddrI; Cyp27b; P450c1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13115

Summary

Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in several structures, including lower jaw molar; metanephros; and testis. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (Cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp27b1 Products (1)

mRNA Protein Name
NM_010009.2 NP_034139.2 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcidiol 1-monooxygenase activity IDA
IDA: Inferred from direct assay
9295274 MGI
Biological Process GO Annotation Evidence References Source
involved in calcitriol biosynthetic process from calciol IDA
IDA: Inferred from direct assay
15972816 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
12205031 MGI
involved in response to vitamin D IDA
IDA: Inferred from direct assay
9295274 MGI
involved in vitamin D catabolic process IDA
IDA: Inferred from direct assay
9295274 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

  • 1alpha(OH)ase

  • 25(OH)D 1alpha-hydroxylase

  • 25-OHD-1 alpha-hydroxylase

  • 25-hydroxyvitamin D(3) 1-alpha-hydroxylase

  • 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS25766 Cyp27b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp27b1 NCBI NCBI:1594