Cyp7b1 - cytochrome P450, family 7, subfamily b, polypeptide 1 Gene

Also Known as hct-1; D3Ertd552e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13123

Summary

Enables oxysterol 7-alpha-hydroxylase activity. Involved in B cell chemotaxis and bile acid biosynthetic process. Acts upstream of or within negative regulation of intracellular Estrogen receptor signaling pathway; positive regulation of epithelial cell proliferation; and prostate gland epithelium morphogenesis. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (Cytochrome P450 family 7 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp7b1 Products (2)

mRNA Protein Name
NM_001409876.1 NP_001396805.1 cytochrome P450 7B1 isoform 2
NM_007825.5 NP_031851.3 cytochrome P450 7B1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables oxysterol 7-alpha-hydroxylase activity IDA
IDA: Inferred from direct assay
10748047 MGI
enables oxysterol 7-alpha-hydroxylase activity IMP
IMP: Inferred from mutant phenotype
22999953 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell chemotaxis IMP
IMP: Inferred from mutant phenotype
22999953 MGI
involved in bile acid biosynthetic process IDA
IDA: Inferred from direct assay
10748047 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
12370428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 7B1

  • 24-hydroxycholesterol 7-alpha-hydroxylase

  • 25-hydroxycholesterol 7-alpha-hydroxylase

  • 25/26-hydroxycholesterol 7-alpha-hydroxylase

  • 3-hydroxysteroid 7-alpha hydroxylase

  • cytochrome P450, 7b1

  • hippocampal transcript 1 protein

  • oxysterol 7-alpha-hydroxylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03488 CYP7B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18706 Cyp7b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25193 Cyp7b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp7b1 NCBI NCBI:9420