Daxx - Fas death domain-associated protein Gene

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 13163

Summary

Enables histone binding activity and transcription coactivator activity. Involved in nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of transcription, DNA-templated; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in islet cell tumor and ovary epithelial Cancer. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Daxx Products (3)

mRNA	Protein	Name
NM_001199733.1	NP_001186662.1	death domain-associated protein 6
NM_001355704.1	NP_001342633.1	death domain-associated protein 6
NM_007829.4	NP_031855.3	death domain-associated protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables histone binding	IDA IDA: Inferred from direct assay	20211137	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9215629	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11799127	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	12917339	MGI
involved in cell population proliferation	IGI IGI: Inferred from genetic interaction	15781341	MGI
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15252119	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12529400	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10444590	MGI
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	20651253	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10684855	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	10684855	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22500635	MGI
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	17081986	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	10444590	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
located in PML body	IDA IDA: Inferred from direct assay	10684855	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10684855	MGI
colocalizes with heterochromatin	IDA IDA: Inferred from direct assay	17081986	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	15252119	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10444590	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
death domain-associated protein 6	death-domain associated protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03535	DAXX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19318	Daxx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25809	Daxx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Daxx	NCBI	NCBI:1616