Ddx4 - DEAD box helicase 4 Gene

Also Known as Mvh; VASA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13206

Summary

Predicted to enable RNA binding activity and RNA helicase activity. Involved in gamete generation; negative regulation of transposition; and piRNA biosynthetic process. Acts upstream of or within male meiosis I and regulation of protein localization. Located in cytoplasmic ribonucleoprotein granule; nucleus; and perinuclear region of cytoplasm. Part of ribonucleoprotein complex. Is expressed in alimentary system mesentery; primordial germ cell; reproductive system; surface ectoderm; and urogenital ridge. Orthologous to human DDX4 (DEAD-box helicase 4). [provided by Alliance of Genome Resources, Apr 2022]

Ddx4 Products (2)

mRNA Protein Name
NM_001145885.1 NP_001139357.1 ATP-dependent RNA helicase DDX4 isoform 1
NM_010029.2 NP_034159.1 ATP-dependent RNA helicase DDX4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
28633017 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14648869 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
10766740 MGI
involved in male meiosis I IMP
IMP: Inferred from mutant phenotype
28633017 MGI
involved in male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
20439430 MGI
involved in piRNA processing IMP
IMP: Inferred from mutant phenotype
20439430 MGI
acts upstream of positive effect piRNA-mediated retrotransposon silencing by heterochromatin formation IMP
IMP: Inferred from mutant phenotype
28633017 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17141210 MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation IMP
IMP: Inferred from mutant phenotype
20439430 MGI
involved in secondary piRNA processing IMP
IMP: Inferred from mutant phenotype
28633017 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
10766740 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
20439430 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatoid body IDA
IDA: Inferred from direct assay
10781947 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10781947 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12798292 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10781947 MGI
located in pi-body IDA
IDA: Inferred from direct assay
20011505 MGI
located in piP-body IDA
IDA: Inferred from direct assay
20011505 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17141210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX4

  • D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 4

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

  • DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 4

  • DEAD box polypeptide 4

  • DEAD box protein 4

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polyp

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03648 DDX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22135 Ddx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28656 Ddx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx4 NCBI NCBI:54514