DDX4 - DEAD-box helicase 4 Gene

Also Known as VASA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54514

About DDX4

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,738,061-55,817,157 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 38 paralogues. Restricted expression toward testis (RPKM 81.5).

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several Other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

DDX4 Products (4)

mRNA	Protein	Name
NM_001142549.2	NP_001136021.1	probable ATP-dependent RNA helicase DDX4 isoform 2
NM_001166533.2	NP_001160005.1	probable ATP-dependent RNA helicase DDX4 isoform 3
NM_001166534.2	NP_001160006.1	probable ATP-dependent RNA helicase DDX4 isoform 4
NM_024415.3	NP_077726.1	probable ATP-dependent RNA helicase DDX4 isoform 1

DDX4 Protein Structure

DEAD

Helicase_C

0
200
400
600
724 a.a.

Protein Preferred Names	Protein Names
probable ATP-dependent RNA helicase DDX4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

DDX4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81463	DDX4 Antibody (YA1208)	IHC-P	Human
HY-P81463A	DDX4 Antibody (YA1208)(PBS only)	IHC-P	Human
HY-P85121	DDX4 Antibody (YA4813)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P86074	DDX4 Antibody (YA5766)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Infertility
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Testicular Torsion	Spermatic Cord Torsion Torsion Of Testis Torsion Of Testicular Cord Torsion Of Testicle Torsion Of Spermatic Cord Torsion Of Spermatic Cord Nos
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy	Familial Amyloid Neuropathy, Finnish Type Familial Amyloid Polyneuropathy, Type V
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03648	DDX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22135	Ddx4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28656	Ddx4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DDX4	VGNC	VGNC:71667
Rattus norvegicus	DDX4	RGD	RGD:1308793
Canis familiaris	DDX4	VGNC	VGNC:39856
Mus musculus	DDX4	MGD	MGI:102670
Bos taurus	DDX4	VGNC	VGNC:27966
Felis catus	DDX4	VGNC	VGNC:97397
Others	DDX4	NCBI