Dlx3 - distal-less homeobox 3 Gene

Also Known as Dlx-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13393

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and placenta development. Located in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Dlx3 Products (1)

mRNA Protein Name
NM_010055.4 NP_034185.1 homeobox protein DLX-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22351765 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18684741 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22351765 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
35922041 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
23371388 MGI
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18684741 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
9874789 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in hair cell differentiation IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in hair cycle IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in hair follicle cell proliferation IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in hair follicle development IMP
IMP: Inferred from mutant phenotype
18684741 MGI
involved in hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
18684741 MGI
acts upstream of or within odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
22351765 MGI
involved in odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
22351765 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
22351765 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
9874789 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23371388 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
35922041 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein DLX-3

  • DII C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03814 DLX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21323 Dlx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27842 Dlx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlx3 NCBI NCBI:1747