Dvl1 - dishevelled segment polarity protein 1 Gene

Also Known as Dvl; mKIAA4029

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13542

Summary

The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 Amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Dvl1 Products (2)

mRNA Protein Name
NM_001356381.1 NP_001343310.1 segment polarity protein dishevelled homolog DVL-1 isoform 2
NM_010091.5 NP_034221.3 segment polarity protein dishevelled homolog DVL-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
21880741 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11113207 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
22899650 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
14966280 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
14966280 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
16116426 MGI
acts upstream of or within axon extension IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
14734535 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
14648878 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
10409711 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11742004 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
16116426 MGI
acts upstream of or within collateral sprouting IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within convergent extension involved in neural plate elongation IGI
IGI: Inferred from genetic interaction
16571627 MGI
acts upstream of or within convergent extension involved in organogenesis IGI
IGI: Inferred from genetic interaction
16116426 MGI
acts upstream of or within convergent extension involved in organogenesis IMP
IMP: Inferred from mutant phenotype
16116426 MGI
acts upstream of or within cytoplasmic microtubule organization IDA
IDA: Inferred from direct assay
14648878 MGI
acts upstream of or within cytoplasmic microtubule organization IGI
IGI: Inferred from genetic interaction
14648878 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
15608632 MGI
involved in heart looping IGI
IGI: Inferred from genetic interaction
22841628 MGI
acts upstream of or within negative regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
9271238 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
12165471 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
16818724 MGI
involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
22841628 MGI
acts upstream of or within positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15548427 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
24305805 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
21670302 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
21670302 MGI
acts upstream of or within prepulse inhibition IMP
IMP: Inferred from mutant phenotype
9298901 MGI
involved in presynapse assembly IDA
IDA: Inferred from direct assay
16818724 MGI
involved in presynapse assembly IMP
IMP: Inferred from mutant phenotype
16818724 MGI
acts upstream of or within protein localization to microtubule IGI
IGI: Inferred from genetic interaction
18716223 MGI
involved in protein stabilization IGI
IGI: Inferred from genetic interaction
26359454 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
12165471 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
23826333 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
23826333 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
14734535 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
26400647 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
26400647 MGI
acts upstream of or within skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
19020093 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
9298901 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
16818724 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
16818724 MGI
acts upstream of positive effect synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
16818724 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26400647 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26400647 MGI
part of Wnt signalosome IDA
IDA: Inferred from direct assay
22899650 MGI
located in axon IDA
IDA: Inferred from direct assay
14734535 MGI
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
17005174 MGI
colocalizes with cytoplasm IDA
IDA: Inferred from direct assay
12138115 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11113207 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
21189423 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21670302 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
21670302 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21670302 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
14734535 MGI
is active in neuronal dense core vesicle EXP
EXP: Inferred from Experiment
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
21321602 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12138115 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21670302 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
21670302 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
16818724 MGI
is active in presynapse IMP
IMP: Inferred from mutant phenotype
16818724 MGI
located in synapse IDA
IDA: Inferred from direct assay
16818724 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

segment polarity protein dishevelled homolog DVL-1

  • DSH homolog 1

  • dishevelled, dsh homolog 1

  • dishevelled-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04076 DVL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20720 Dvl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27232 Dvl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dvl1 NCBI NCBI:1855