CPA3 - carboxypeptidase A3 Gene

Also Known as MC-CPA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1359

About CPA3

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,865,296-148,897,203 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 8 paralogues. Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues.

Summary

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

CPA3 Products (1)

mRNA Protein Name
NM_001870.4 NP_001861.2 mast cell carboxypeptidase A preproprotein

CPA3 Protein Structure

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (27 - 103)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (125 - 403)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

mast cell carboxypeptidase A

  • carboxypeptidase A3 (mast cell)

Related Diseases

Diseases Alias
Thiopental Allergy

  • Penthiobarbital Allergy

  • Pentothiobarbital Allergy
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities

  • X-Linked Dyserythropoietic Anemia

  • X-Linked Dyserythropoietic Anemia With Abnormal Platelets And Neutropenia

  • XLANP

  • Anemia, X-Linked, With/Without Neutropenia And/Or Platelet Abnormalities

  • X-Linked Anemia With/Without Neutropenia And/Or Platelet Abnormalities

  • Anemia Without Thrombocytopenia, X-Linked

  • XLAWT

  • Anemia X-Linked With Variable Neutropenia
Factitious Disorder

  • Munchausen Syndrome

  • Factitious Disorders

  • Münchausen Syndrome
Exercise-Induced Bronchoconstriction

  • Exercise-Induced Asthma

  • Asthma Exercise-Induced
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-70005 CPA inhibitor 99.78% Unkown
HY-RS03082 CPA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03083 CPA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CPA3 RGD RGD:2390
Mus musculus CPA3 MGD MGI:88479
Felis catus CPA3 VGNC VGNC:61113
Canis familiaris CPA3 VGNC VGNC:39544
Bos taurus CPA3 VGNC VGNC:27643
Macaca mulatta CPA3 VGNC VGNC:71456
Others CPA3 NCBI