CPA3 - carboxypeptidase A3 Gene

Homo sapiens

Also known as MC-CPA

Gene ID: 1359 | Gene type: protein coding

About CPA3

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,865,296-148,897,203 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 8 paralogues. Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues.

Summary

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated Peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

CPA3 Products(1)

mRNA	Protein	Name
NM_001870.4	NP_001861.2	mast cell carboxypeptidase A preproprotein

CPA3 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

mast cell carboxypeptidase A

carboxypeptidase A3 (mast cell)

Related Diseases

Diseases

Alias

Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities

X-Linked Dyserythropoietic Anemia	X-Linked Dyserythropoietic Anemia With Abnormal Platelets And Neutropenia
XLANP	Anemia, X-Linked, With/Without Neutropenia And/Or Platelet Abnormalities
X-Linked Anemia With/Without Neutropenia And/Or Platelet Abnormalities	Anemia Without Thrombocytopenia, X-Linked
XLAWT	Anemia X-Linked With Variable Neutropenia

Factitious Disorder

Munchausen Syndrome	Factitious Disorders
Münchausen Syndrome

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03082	CPA3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CPA3	RGD	RGD:2390
Mus musculus	CPA3	MGD	MGI:88479
Felis catus	CPA3	VGNC	VGNC:61113
Canis familiaris	CPA3	VGNC	VGNC:39544
Bos taurus	CPA3	VGNC	VGNC:27643
Macaca mulatta	CPA3	VGNC	VGNC:71456