Eif4ebp2 - eukaryotic translation initiation factor 4E binding protein 2 Gene

Also Known as 4E-BP2; PHAS-II; 2810011I19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13688

Summary

Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and Insulin Receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif4ebp2 Products (1)

mRNA Protein Name
NM_010124.2 NP_034254.1 eukaryotic translation initiation factor 4E-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables eukaryotic initiation factor 4E binding IMP
IMP: Inferred from mutant phenotype
20347422 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8939971 MGI
enables translation repressor activity IMP
IMP: Inferred from mutant phenotype
16237163 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within TOR signaling IDA
IDA: Inferred from direct assay
8939971 MGI
involved in TOR signaling IMP
IMP: Inferred from mutant phenotype
20347422 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
8939971 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
16237163 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
20347422 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
23172145 MGI
involved in negative regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
16237163 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
16237163 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
17029989 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E-binding protein 2

  • eIF4E-binding protein 2

  • phosphorylated heat- and acid-stable protein regulated by insulin 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4ebp2 NCBI NCBI:1979