GAB3 - GRB2 associated binding protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139716

About GAB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,675,249-154,751,566 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in spleen (RPKM 7.6), bone marrow (RPKM 4.4) and 22 other tissues.

Summary

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine Phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GAB3 Products (3)

mRNA Protein Name
NM_001081573.3 NP_001075042.1 GRB2-associated-binding protein 3 isoform 1
NM_001282283.2 NP_001269212.1 GRB2-associated-binding protein 3 isoform 3
NM_080612.4 NP_542179.1 GRB2-associated-binding protein 3 isoform 2

GAB3 Protein Structure

PH

PH: PH domain (8 - 116)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 586 a.a.
Protein Preferred Names Protein Names

GRB2-associated-binding protein 3

  • DOS/Gab family member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05199 GAB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20737 Gab3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GAB3 VGNC VGNC:72736
Bos taurus GAB3 VGNC VGNC:29184
Felis catus GAB3 VGNC VGNC:62413
Mus musculus GAB3 MGD MGI:2387324
Canis familiaris GAB3 VGNC VGNC:54143
Others GAB3 NCBI