Eya1 - EYA transcriptional coactivator and phosphatase 1 Gene

Also Known as bor

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14048

Summary

Enables RNA binding activity and protein tyrosine Phosphatase activity. Involved in mesodermal cell fate specification; positive regulation of transcription, DNA-templated; and protein sumoylation. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in cytoplasm and nucleus. Part of protein-DNA complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study branchiootorenal syndrome. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eya1 Products (7)

mRNA Protein Name
NM_001252192.2 NP_001239121.1 eyes absent homolog 1 isoform 2
NM_001310459.2 NP_001297388.1 eyes absent homolog 1 isoform 3
NM_001402659.1 NP_001389588.1 eyes absent homolog 1 isoform 4
NM_001402660.1 NP_001389589.1 eyes absent homolog 1 isoform 5
NM_001402661.1 NP_001389590.1 eyes absent homolog 1 isoform 6
NM_001402662.1 NP_001389591.1 eyes absent homolog 1 isoform 7
NM_010164.3 NP_034294.2 eyes absent homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA binding IDA
IDA: Inferred from direct assay
21936910 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11734542 MGI
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
14628052 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
16530750 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12070080 MGI
acts upstream of or within aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
21364285 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
12783782 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
15817220 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
10072433 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
10471511 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16916509 MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
15817220 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16916509 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10471511 MGI
involved in mesodermal cell fate specification IDA
IDA: Inferred from direct assay
17785448 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
10072433 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10471511 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
15817220 MGI
acts upstream of or within neuron fate specification IGI
IGI: Inferred from genetic interaction
22513373 MGI
acts upstream of or within otic vesicle development IGI
IGI: Inferred from genetic interaction
22513373 MGI
acts upstream of or within otic vesicle morphogenesis IMP
IMP: Inferred from mutant phenotype
16916509 MGI
acts upstream of or within outer ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10471511 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
21364285 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
16530750 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
16916509 MGI
acts upstream of or within pharyngeal system development IMP
IMP: Inferred from mutant phenotype
21364285 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17785448 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16916509 MGI
acts upstream of or within positive regulation of secondary heart field cardioblast proliferation IGI
IGI: Inferred from genetic interaction
21364285 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21364285 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
14628052 MGI
involved in protein sumoylation IDA
IDA: Inferred from direct assay
16990542 MGI
acts upstream of or within regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
22513373 MGI
acts upstream of or within regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15496442 MGI
acts upstream of or within semicircular canal morphogenesis IMP
IMP: Inferred from mutant phenotype
10072433 MGI
acts upstream of or within striated muscle tissue development IGI
IGI: Inferred from genetic interaction
17098221 MGI
acts upstream of or within ureteric bud development IGI
IGI: Inferred from genetic interaction
16018995 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16024294 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16024294 MGI
part of protein-DNA complex IDA
IDA: Inferred from direct assay
17785448 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17785448 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eyes absent homolog 1

  • eyes absent 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-158059 DS-1-38 Inhibitor 99.57% Unkown
HY-RS04611 EYA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22165 Eya1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28687 Eya1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eya1 NCBI NCBI:2138