Sox9 - SRY-box transcription factor 9 Gene

Also Known as SRY

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140586

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Sertoli cell development; cAMP-mediated signaling; and positive regulation of macromolecule metabolic process. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in 46,XX sex reversal 2; 46,XY sex reversal 10; and campomelic dysplasia. Orthologous to human SOX9 (SRY-box transcription factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Sox9 Products (1)

mRNA Protein Name
NM_080403.2 NP_536328.1 transcription factor SOX-9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11875113 RGD
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
11514554 RGD
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
19828133 RGD
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10805756 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
11875113 RGD
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
10805756 RGD
involved in cartilage development IEP
IEP: Inferred from expression pattern
15512770 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
19828133 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11875113 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
30599193 RGD
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
19828133 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-9

  • SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)

  • SRY box 9

  • SRY-box containing gene 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-RS13599 SOX9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12540 Monogalactosyldiacylglycerol 99.9% Unkown
HY-RS17376 Sox9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23830 Sox9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox9 NCBI NCBI:6662