Myh7 - myosin, heavy polypeptide 7, cardiac muscle, beta Gene

Also Known as B-MHC; Myhcb; MyHC-I; Myhc-b; betaMHC; beta-MHC; myHC-beta; myHC-slow; MYH-beta/slow

Species: Mus musculus

Gene Type: protein coding
Gene ID: 140781

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and transition between fast and slow fiber. Located in Z disc and stress fiber. Part of Myosin complex. Is expressed in several structures, including diaphragm; eye; heart; musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (Myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]

Myh7 Products (2)

mRNA Protein Name
NM_001361607.1 NP_001348536.1 myosin-7
NM_080728.3 NP_542766.1 myosin-7

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
acts upstream of or within transition between fast and slow fiber IDA
IDA: Inferred from direct assay
18978355 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
21126233 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
25139234 MGI
located in myofibril IDA
IDA: Inferred from direct assay
9884344 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
8482409 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
21126233 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-7

  • myosin heavy chain 7

  • myosin heavy chain, cardiac muscle, fetal

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08905 MYH7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08906 MYH7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20779 Myh7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27293 Myh7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27903 Myh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh7 NCBI NCBI:4625