Fanca - Fanconi anemia, complementation group A Gene

Also Known as FACA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14087

Summary

Acts upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including gut; liver; lung; reproductive system; and spleen. Used to study Fanconi anemia complementation group A. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A). [provided by Alliance of Genome Resources, Apr 2022]

Fanca Products (1)

mRNA Protein Name
NM_016925.4 NP_058621.2 Fanconi anemia group A protein homolog

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
12913077 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
12913077 MGI
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
12913077 MGI
acts upstream of or within regulation of CD40 signaling pathway IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of germ cell proliferation IMP
IMP: Inferred from mutant phenotype
12913077 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
24501220 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Fanconi anemia group A protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04732 FANCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19192 Fanca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25680 Fanca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fanca NCBI NCBI:2175