Daxx - death-domain associated protein Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 140926

Summary

Enables JUN kinase binding activity; Androgen Receptor binding activity; and Kinesin binding activity. Involved in several processes, including PML body organization; cellular response to anoxia; and positive regulation of histone phosphorylation. Located in several cellular components, including PML body; XY body; and microtubule. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in islet cell tumor and ovary epithelial Cancer. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Daxx Products (1)

mRNA	Protein	Name
NM_080891.2	NP_543167.2	death domain-associated protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	18932217	RGD
enables kinesin binding	IPI IPI: Inferred from physical interaction	18932217	RGD
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	15350595	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12786973	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21572393	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in PML body organization	IMP IMP: Inferred from mutant phenotype	17289031	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19017466	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21572393	RGD
involved in cellular response to type II interferon	IMP IMP: Inferred from mutant phenotype	21572393	RGD
involved in negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	17289031	RGD
involved in negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	19308989	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	17289031	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15350595	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17289031	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21572393	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	21572393	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	17692352	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in PML body	IDA IDA: Inferred from direct assay	17289031	RGD
located in XY body	IDA IDA: Inferred from direct assay	15349788	RGD
located in cell body	IDA IDA: Inferred from direct assay	18096138	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	12786973	RGD
located in microtubule	IDA IDA: Inferred from direct assay	18932217	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
death domain-associated protein 6	Fas death domain-associated protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03535	DAXX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19318	Daxx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25809	Daxx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Daxx	NCBI	NCBI:1616