Fhl2 - four and a half LIM domains 2 Gene

Also Known as FHL-2; SLIM3; SLIM-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14200

Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Fhl2 Products (3)

mRNA Protein Name
NM_001289533.2 NP_001276462.1 four and a half LIM domains protein 2
NM_001412598.1 NP_001399527.1 four and a half LIM domains protein 2
NM_010212.5 NP_034342.1 four and a half LIM domains protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
15509787 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15509787 MGI
Biological Process GO Annotation Evidence References Source
involved in atrial cardiac muscle cell development IEP
IEP: Inferred from expression pattern
15509787 MGI
involved in heart trabecula formation IEP
IEP: Inferred from expression pattern
15509787 MGI
involved in negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
22851699 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15509787 MGI
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16311053 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12151099 MGI
involved in ventricular cardiac muscle cell development IEP
IEP: Inferred from expression pattern
15509787 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
22851699 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12151099 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

four and a half LIM domains protein 2

  • skeletal muscle LIM-protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04935 FHL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17638 Fhl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24098 Fhl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fhl2 NCBI NCBI:2274