Fkbp8 - FK506 binding protein 8 Gene

Also Known as 38kDa; FKBP-8; Fkbp38; FKBP-38; FKBPR38; mFKBP38

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14232

Summary

Enables protein folding chaperone. Acts upstream of or within several processes, including dorsal/ventral neural tube patterning; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Located in mitochondrial envelope. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo. Used to study clubfoot. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp8 Products (3)

mRNA Protein Name
NM_001111066.1 NP_001104536.1 peptidyl-prolyl cis-trans isomerase FKBP8 isoform a
NM_001199631.1 NP_001186560.1 peptidyl-prolyl cis-trans isomerase FKBP8 isoform a
NM_010223.2 NP_034353.2 peptidyl-prolyl cis-trans isomerase FKBP8 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29916806 MGI
enables protein folding chaperone IMP
IMP: Inferred from mutant phenotype
29916806 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18590716 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
18003640 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
15105374 MGI
acts upstream of or within cell fate specification IMP
IMP: Inferred from mutant phenotype
18590716 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
18590716 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
18003640 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
15105374 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
18590716 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18003640 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
18590716 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
15105374 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18590716 MGI
acts upstream of or within protein folding IMP
IMP: Inferred from mutant phenotype
29916806 MGI
acts upstream of or within regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18590716 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
18590716 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
15105374 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
15105374 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15105374 MGI
located in mitochondrial envelope IDA
IDA: Inferred from direct assay
15105374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP8

  • 38 kDa FK506-binding protein

  • 38 kDa FKBP

  • FK506-binding protein 38

  • PPIase FKBP8

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04968 FKBP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20408 Fkbp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26917 Fkbp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp8 NCBI NCBI:23770