Lpin1 - lipin 1 Gene

Also Known as fld; Lipin1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14245

Summary

Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate Phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of cold-induced thermogenesis; and triglyceride mobilization. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; positive regulation of histone deacetylation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpin1 Products (4)

mRNA Protein Name
NM_001130412.1 NP_001123884.1 phosphatidate phosphatase LPIN1 isoform a
NM_001355598.1 NP_001342527.1 phosphatidate phosphatase LPIN1 isoform b
NM_015763.4 NP_056578.2 phosphatidate phosphatase LPIN1 isoform b
NM_172950.3 NP_766538.2 phosphatidate phosphatase LPIN1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
20385772 MGI
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
20385772 MGI
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
16950137 MGI
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
17158099 MGI
enables phosphatidate phosphatase activity IGI
IGI: Inferred from genetic interaction
24133206 MGI
enables phosphatidate phosphatase activity IMP
IMP: Inferred from mutant phenotype
24133206 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16950137 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16950137 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
10438476 MGI
acts upstream of or within cellular lipid metabolic process IMP
IMP: Inferred from mutant phenotype
22337502 MGI
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
10438476 MGI
involved in fatty acid catabolic process IDA
IDA: Inferred from direct assay
16950137 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
22337502 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
2722772 MGI
involved in mitochondrial fission IDA
IDA: Inferred from direct assay
21397848 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20385772 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23028044 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16950137 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20385772 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
11138012 MGI
acts upstream of or within ruffle organization IMP
IMP: Inferred from mutant phenotype
10438476 MGI
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
24133206 MGI
involved in triglyceride mobilization IDA
IDA: Inferred from direct assay
16950137 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19753306 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26475860 MGI
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
17105729 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
21397848 MGI
located in nuclear membrane IDA
IDA: Inferred from direct assay
22134922 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11138012 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
20385772 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidate phosphatase LPIN1

  • fatty liver dystrophy protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19455 Lpin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07769 LPIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25948 Lpin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpin1 NCBI NCBI:23175