Fmr1 - fragile X messenger ribonucleoprotein 1 Gene

Also Known as FMRP; Fmr-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14265

Summary

Enables several functions, including RNA binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular protein metabolic process; and regulation of mRNA metabolic process. Acts upstream of or within central nervous system development and dendritic spine development. Located in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic ribonucleoprotein granule; and filopodium. Is extrinsic component of plasma membrane. Part of SMN complex; mRNA cap binding activity complex; and polysome. Is active in presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (FMRP translational regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Fmr1 Products (6)

mRNA Protein Name
NM_001290424.2 NP_001277353.1 fragile X messenger ribonucleoprotein 1 isoform 2
NM_001374719.1 NP_001361648.1 fragile X messenger ribonucleoprotein 1 isoform 3
NM_001412089.1 NP_001399018.1 fragile X messenger ribonucleoprotein 1 isoform 4
NM_001412090.1 NP_001399019.1 fragile X messenger ribonucleoprotein 1 isoform 5
NM_001412091.1 NP_001399020.1 fragile X messenger ribonucleoprotein 1 isoform 6
NM_008031.4 NP_032057.2 fragile X messenger ribonucleoprotein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
31340148 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
24349419 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24813610 MGI
enables dynein complex binding IDA
IDA: Inferred from direct assay
18539120 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
11376146 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
14613971 MGI
enables miRNA binding IDA
IDA: Inferred from direct assay
20159450 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
17881655 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10567518 MGI
enables translation repressor activity IDA
IDA: Inferred from direct assay
11376146 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA repair IDA
IDA: Inferred from direct assay
24813610 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
12700164 MGI
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
23509247 MGI
involved in excitatory chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
30679017 MGI
involved in glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
18539120 MGI
involved in glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11438589 MGI
involved in inhibitory chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
30679017 MGI
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
31340148 MGI
involved in mRNA transport IDA
IDA: Inferred from direct assay
18539120 MGI
acts upstream of or within positive effect miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
20159450 MGI
involved in negative regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11376146 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23235829 MGI
involved in negative regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
11438589 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
14613971 MGI
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
27666021 MGI
involved in negative regulation of translational initiation IDA
IDA: Inferred from direct assay
18805096 MGI
involved in positive regulation of dendritic spine development IDA
IDA: Inferred from direct assay
18539120 MGI
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
18539120 MGI
involved in positive regulation of proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
24709664 MGI
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
19166269 MGI
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
18653529 MGI
involved in regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
16631377 MGI
involved in regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16631377 MGI
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
17417632 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
12032354 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
12032354 MGI
involved in response to interleukin-17 IMP
IMP: Inferred from mutant phenotype
31853066 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
31853066 MGI
involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
29901787 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
12032354 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
12032354 MGI
located in axon IDA
IDA: Inferred from direct assay
16631377 MGI
located in chromocenter IDA
IDA: Inferred from direct assay
24813610 MGI
located in chromosome IDA
IDA: Inferred from direct assay
24813610 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15805463 MGI
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
18539120 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21933836 MGI
located in dendrite IDA
IDA: Inferred from direct assay
16631377 MGI
located in dendritic filopodium IDA
IDA: Inferred from direct assay
16631377 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
16631377 MGI
located in filopodium tip IDA
IDA: Inferred from direct assay
16631377 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19193898 MGI
located in growth cone filopodium IDA
IDA: Inferred from direct assay
16631377 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
19193898 MGI
located in neuronal ribonucleoprotein granule IDA
IDA: Inferred from direct assay
18539120 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
12700164 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12700164 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
14613971 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16790844 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
19193898 MGI
located in presynapse IDA
IDA: Inferred from direct assay
19193898 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
19193898 MGI
located in synapse IDA
IDA: Inferred from direct assay
16631377 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fragile X messenger ribonucleoprotein 1

synaptic functional regulator FMR1

  • FMRP translational regulator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100786 DL-AP3 ≥98.0% Unkown
HY-160887 FPT Agonist 98.06% Unkown
HY-181828 SePP Antagonist / Unkown
HY-RS05011 FMR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05012 FMR1NB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185723 rG4 WT_AHPC_PEG2 99.80% Unkown
HY-RS19332 Fmr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25823 Fmr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fmr1 NCBI NCBI:2332