Fosl2 - fos-like antigen 2 Gene

Also Known as Fra-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14284

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within keratinocyte development; positive regulation of fibroblast proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; skeleton; skin; and telencephalon. Used to study idiopathic pulmonary fibrosis and systemic scleroderma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosl2 Products (1)

mRNA Protein Name
NM_008037.4 NP_032063.2 fos-related antigen 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24464219 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19289495 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
25547114 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
22326952 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
28566276 MGI
acts upstream of or within B cell proliferation IMP
IMP: Inferred from mutant phenotype
28566276 MGI
acts upstream of or within NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
19620306 MGI
acts upstream of or within T cell differentiation IDA
IDA: Inferred from direct assay
32610127 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
32610127 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
32610127 MGI
acts upstream of or within T-helper 2 cell cytokine production IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within alveolar secondary septum development IMP
IMP: Inferred from mutant phenotype
28818870 MGI
acts upstream of or within bone development IDA
IDA: Inferred from direct assay
24046454 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
24046454 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within chemokine (C-C motif) ligand 11 production IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within chemokine production IDA
IDA: Inferred from direct assay
33655757 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
20837772 MGI
acts upstream of or within collagen metabolic process IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
33655757 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within fat cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24464219 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
24464219 MGI
acts upstream of or within fat pad development IMP
IMP: Inferred from mutant phenotype
24464219 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
22326952 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within glucose homeostasis IDA
IDA: Inferred from direct assay
24046454 MGI
acts upstream of or within granulocyte macrophage colony-stimulating factor production IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within growth plate cartilage development IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
19620306 MGI
acts upstream of or within homeostasis of number of cells within a tissue IDA
IDA: Inferred from direct assay
33655757 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
24464219 MGI
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
32610127 MGI
acts upstream of or within inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
19620306 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within insulin metabolic process IDA
IDA: Inferred from direct assay
24046454 MGI
acts upstream of or within interleukin-2 production IMP
IMP: Inferred from mutant phenotype
19620306 MGI
acts upstream of or within interleukin-4 production IMP
IMP: Inferred from mutant phenotype
19620306 MGI
acts upstream of or within keratinocyte development IMP
IMP: Inferred from mutant phenotype
25547114 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
28818870 MGI
acts upstream of or within lung connective tissue development IMP
IMP: Inferred from mutant phenotype
31135379 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within macrophage differentiation IDA
IDA: Inferred from direct assay
31135379 MGI
acts upstream of or within macrophage differentiation IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within mucus secretion IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15509771 MGI
acts upstream of or within myofibroblast differentiation IMP
IMP: Inferred from mutant phenotype
28818870 MGI
acts upstream of or within neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
20837772 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20837772 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
18548006 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22585681 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
7936655 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25547114 MGI
acts upstream of or within regulation of multicellular organism growth IDA
IDA: Inferred from direct assay
24046454 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
24046454 MGI
acts upstream of or within regulation of myofibroblast differentiation IDA
IDA: Inferred from direct assay
31135379 MGI
acts upstream of or within regulation of myofibroblast differentiation IMP
IMP: Inferred from mutant phenotype
31135379 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
28566276 MGI
acts upstream of or within response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
33655757 MGI
acts upstream of or within response to bleomycin IDA
IDA: Inferred from direct assay
31135379 MGI
acts upstream of or within response to glucocorticoid IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within response to interleukin-13 IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within response to interleukin-7 IMP
IMP: Inferred from mutant phenotype
28566276 MGI
acts upstream of or within response to leukemia inhibitory factor IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
30181393 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within smooth muscle tissue development IDA
IDA: Inferred from direct assay
30233597 MGI
acts upstream of or within tissue remodeling IDA
IDA: Inferred from direct assay
30233597 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25547114 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fos-related antigen 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18065 Fosl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05035 FOSL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24540 Fosl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fosl2 NCBI NCBI:2355