Xrcc6 - X-ray repair complementing defective repair in Chinese hamster cells 6 Gene

Also Known as Ku70; 70kDa; G22p1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14375

Summary

Enables double-stranded DNA binding activity. Involved in positive regulation of lymphocyte differentiation. Acts upstream of or within DNA metabolic process; positive regulation of neurogenesis; and response to ionizing radiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver lobe; and telencephalon ventricular layer. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc6 Products (3)

mRNA Protein Name
NM_001411249.1 NP_001398178.1 X-ray repair cross-complementing protein 6 isoform 1
NM_001411250.1 NP_001398179.1 X-ray repair cross-complementing protein 6 isoform 2
NM_010247.3 NP_034377.2 X-ray repair cross-complementing protein 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
20150414 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12551933 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15979950 MGI
acts upstream of or within V(D)J recombination IMP
IMP: Inferred from mutant phenotype
10716994 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
11751629 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
11751629 MGI
acts upstream of neurogenesis IMP
IMP: Inferred from mutant phenotype
10716994 MGI
involved in positive regulation of lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
32103174 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
10716994 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
15979950 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12604618 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12604618 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

X-ray repair cross-complementing protein 6

  • 5'-dRP/AP lyase Ku70

  • 5'-deoxyribose-5-phosphate lyase Ku70

  • ATP-dependent DNA helicase 2 subunit 1

  • ATP-dependent DNA helicase II 70 kDa subunit

  • CTC box-binding factor 75 kDa subunit

  • CTC75

  • CTCBF

  • DNA repair protein XRCC6

  • Ku p70

  • ku autoantigen protei

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15901 XRCC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19756 Xrcc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26253 Xrcc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrcc6 NCBI NCBI:2547