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Gata2 - GATA binding protein 2 Gene

Also Known as Gata-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14461

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including animal organ development; regulation of myeloid cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gata2 Products (2)

mRNA	Protein	Name
NM_001355253.1	NP_001342182.1	endothelial transcription factor GATA-2
NM_008090.5	NP_032116.4	endothelial transcription factor GATA-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10367888	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7720565	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17962413	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18184866	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10367888	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11724781	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	22991444	MGI
acts upstream of angiogenesis	IMP IMP: Inferred from mutant phenotype	9043071	MGI
acts upstream of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	16082385	MGI
acts upstream of or within cell differentiation in hindbrain	IMP IMP: Inferred from mutant phenotype	10357893	MGI
acts upstream of or within cell fate determination	IDA IDA: Inferred from direct assay	10367888	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	10357893	MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain	IMP IMP: Inferred from mutant phenotype	22991444	MGI
acts upstream of or within definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	8078582	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	9043071	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	16621992	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	15811962	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	14504093	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	15811962	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	20652952	MGI
acts upstream of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	16621992	MGI
acts upstream of or within negative regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	16082385	MGI
acts upstream of or within negative regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	16621992	MGI
acts upstream of or within negative regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	16254139	MGI
acts upstream of or within negative regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	16621992	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16672344	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16082385	MGI
acts upstream of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	16672344	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16672344	MGI
acts upstream of or within neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	10357893	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	19088086	MGI
acts upstream of or within neuron maturation	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of or within positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	9043071	MGI
acts upstream of or within positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	16254139	MGI
acts upstream of or within positive regulation of megakaryocyte differentiation	IDA IDA: Inferred from direct assay	16254139	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7720565	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9305891	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9043071	MGI
acts upstream of or within regulation of forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	22991444	MGI
acts upstream of or within regulation of primitive erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	14504093	MGI
acts upstream of or within semicircular canal development	IMP IMP: Inferred from mutant phenotype	20652952	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16082385	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	16543408	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9043071	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	9822612	MGI
acts upstream of or within ventral spinal cord interneuron differentiation	IMP IMP: Inferred from mutant phenotype	10934027	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9305891	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19323994	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endothelial transcription factor GATA-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05290	GATA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174676	Human GATA2 mRNA		/	Unkown
HY-RS20027	Gata2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26530	Gata2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata2	NCBI	NCBI:2624