CSRP1 - cysteine and glycine rich protein 1 Gene

Also Known as CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141; HEL-S-286

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1465

About CSRP1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,483,530-201,507,123 (from NCBI)

This gene has 19 transcripts (splice variants), 261 orthologues and 2 paralogues. Broad expression in prostate (RPKM 425.1), endometrium (RPKM 406.6) and 22 other tissues.

Summary

This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

CSRP1 Products (4)

mRNA Protein Name
NM_001193570.2 NP_001180499.1 cysteine and glycine-rich protein 1 isoform 3
NM_001193571.2 NP_001180500.1 cysteine and glycine-rich protein 1 isoform 1
NM_001193572.2 NP_001180501.1 cysteine and glycine-rich protein 1 isoform 1
NM_004078.3 NP_004069.1 cysteine and glycine-rich protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
26924529 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSRP1 Protein Structure

LIM

LIM: LIM domain (10 - 65)

LIM

LIM: LIM domain (119 - 175)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

cysteine and glycine-rich protein 1

  • LIM-domain protein

CSRP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSRP1 P21291 CA9 Homo sapiens Q16790
Validated Y2H
32296183
Intra
CSRP1 P21291 CA9 Homo sapiens Q16790
Y2H Array
32296183
Intra
CSRP1 P21291 CA9 Homo sapiens Q16790
Y2H Prey Pooling
32296183
Intra
CSRP1 P21291 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
CSRP1 P21291 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
CSRP1 P21291 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSRP1 Proteins

Cat. No. Product Name Accession Purity
HY-P76298 CSRP1 Protein, Human (His) P21291 (M1-E193) ≥ 95%, as determined by reducing SDS-PAGE.

CSRP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810862 CSRP1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Endocardial Fibroelastosis

  • Endomyocardial Fibroelastosis

  • Elastomyofibrosis

  • EFE

  • Efe - [Endocardial Fibroelastosis]

  • Primary Endocardial Fibroelastosis

  • Fibroelastosis Cordis

  • Fetal Endocarditis

  • Fibroelastosis

  • Congenital Endocardial Fibroelastosis

  • Congenital Valvular Endocarditis
Mixed Hepatoblastoma

  • Mixed Epithelial And Mesenchymal Hepatoblastoma
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03258 CSRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18515 Csrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24997 Csrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CSRP1 VGNC VGNC:71527
Felis catus CSRP1 VGNC VGNC:61233
Canis familiaris CSRP1 VGNC VGNC:39675
Mus musculus CSRP1 MGD MGI:88549
Bos taurus CSRP1 VGNC VGNC:27773
Rattus norvegicus CSRP1 RGD RGD:62053
Others CSRP1 NCBI