2. Gene
  3. SLC47A2 - solute carrier family 47 member 2 Gene

SLC47A2 - solute carrier family 47 member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MATE2; MATE2K; MATE2-B; MATE2-K

Gene ID: 146802 | Gene type: protein coding

About SLC47A2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,678,317-19,718,979 (from NCBI)

This gene has 10 transcripts (splice variants), 282 orthologues and 1 paralogue. Restricted expression toward kidney (RPKM 17.1).

Summary

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the Bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SLC47A2 Products(3)

mRNA Protein Name
NM_001099646.3 NP_001093116.1 multidrug and toxin extrusion protein 2 isoform 2
NM_001256663.3 NP_001243592.1 multidrug and toxin extrusion protein 2 isoform 3
NM_152908.5 NP_690872.2 multidrug and toxin extrusion protein 2 isoform 1

SLC47A2 Protein Structure

MatE

MatE: MatE (40 - 181)

MatE

MatE: MatE (297 - 458)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

multidrug and toxin extrusion protein 2

kidney-specific H(+)/organic cation antiporter

Related Diseases

Diseases Alias
Thiamine Metabolism Dysfunction Syndrome 2

Biotin-Responsive Basal Ganglia Disease

Basal Ganglia Disease, Biotin-Responsive

THMD2

Bbgd

Btbgd

Encephalopathy, Thiamine-Responsive

Thiamine Metabolism Dysfunction Syndrome 2, Biotin- Or Thiamine-Responsive Type

Thiamine-Responsive Encephalopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13264 SLC47A2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC47A2 RGD RGD:1562382
Canis familiaris SLC47A2 VGNC VGNC:49831
Macaca mulatta SLC47A2 VGNC VGNC:77778
Bos taurus SLC47A2 VGNC VGNC:34888