Gnas - GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Gene

Also Known as P1; P2; P3; GSP; Gsa; POH; GPSA; Nesp; SCG6; Gnas1; Nespl; PHP1A; PHP1B; Gnasxl; Nesp55; Oedsml; Galphas; Oed-Sml; Gs-alpha; 5530400H20Rik; A930027G11Rik; C130027O20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14683

Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]

Gnas Products (11)

mRNA Protein Name
NM_001077507.2 NP_001070975.1 protein GNAS isoform f
NM_001077510.5 NP_001070978.1 protein GNAS isoform GNASS
NM_001310083.1 NP_001297012.1 protein GNAS isoform GNASL
NM_001310085.1 NP_001297014.1 protein GNAS isoform XXLb2
NM_001364030.1 NP_001350959.1 protein ALEX isoform i
NM_010309.4 NP_034439.2 protein GNAS isoform XLas
NM_019690.3 NP_062664.2 protein SCG6 (secretogranin VI) isoform SCG6 precursor
NM_022000.3 NP_068840.2 protein SCG6 (secretogranin VI) isoform SCG6 precursor
NM_201616.3 NP_963910.1 protein GNAS isoform GNASL
NM_201617.2 NP_963911.1 protein GNAS isoform XXLb1
NM_201618.2 NP_963912.1 protein ALEX isoform Alex

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein activity IDA
IDA: Inferred from direct assay
21467038 MGI
enables G protein activity IMP
IMP: Inferred from mutant phenotype
12145344 MGI
enables adenylate cyclase activator activity IDA
IDA: Inferred from direct assay
17971513 MGI
enables adenylate cyclase regulator activity IMP
IMP: Inferred from mutant phenotype
12145344 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9016340 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
2499043 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17971513 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
33196462 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
2826231 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
34091063 MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17194762 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
15797856 MGI
involved in cellular response to glucagon stimulus IMP
IMP: Inferred from mutant phenotype
16239968 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within energy reserve metabolic process IMP
IMP: Inferred from mutant phenotype
10712433 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
20427744 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
20427744 MGI
involved in negative regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23839232 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
20374964 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
17971513 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
33196462 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
34091063 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within post-embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within regulation of parathyroid hormone secretion IMP
IMP: Inferred from mutant phenotype
15811946 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
11438605 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15797856 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
20427744 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
20427744 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
19966281 MGI
located in membrane IDA
IDA: Inferred from direct assay
9016340 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
9322912 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
17971513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein ALEX

protein GNAS

protein SCG6 (secretogranin VI)

  • Gs alpha subunit

  • adenylate cyclase-stimulating G alpha protein

  • alternative gene product encoded by XL-exon

  • extra large alphas protein

  • neuroendocrine secretory protein 55

  • secretogranin VI

  • stimulatory G-protein alpha subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101508 GNA002 Inhibitor 98.02% Unkown
HY-RS05531 GNA13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05540 GNAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05529 GNA11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05530 GNA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05532 GNA14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05533 GNA15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167993 (R)-GNA-T phosphoramidite / Unkown
HY-177335 (R)-GNA-U phosphoramidite / Unkown
HY-RS17744 Gnas Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19685 Gna14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20938 Gna13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22532 Gna15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24210 Gnas Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26178 Gna14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27455 Gna13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29052 Gna15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1008609 (R)-GNA-A(Bz) phosphoramidite / Unkown
HY-W1008618 (R)-GNA-C(Bz)-phosphoramidite / Unkown
HY-W1008626 (S)-GNA-U-phosphoramidite 96.35% Unkown
HY-W675848 N4-Bz-C-(S)-GNA phosphoramidite / Unkown
HY-W881216 (S)-GNA-T-phosphoramidite / Unkown
HY-W881217 DMT-iBu-G-(S)-GNA Phosphoramidite / Unkown
HY-W881219 N6-Bz-A-(S)-GNA phosphoramidite 98.0% Unkown
HY-W881463 N4-Ac-C-(S)-GNA phosphoramidite / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnas NCBI NCBI:2778