Emg1 - EMG1 N1-specific pseudouridine methyltransferase Gene

Also Known as C2f; Grcc2f

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14791

Summary

Predicted to enable identical protein binding activity; rRNA (pseudouridine) methyltransferase activity; and rRNA binding activity. Acts upstream of or within blastocyst development and nucleologenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and integumental system. Used to study Bowen-Conradi syndrome. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Emg1 Products (7)

mRNA Protein Name
NM_001409781.1 NP_001396710.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 2
NM_001409782.1 NP_001396711.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 3
NM_001409783.1 NP_001396712.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 4
NM_001409784.1 NP_001396713.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 5
NM_001409785.1 NP_001396714.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 6
NM_001409786.1 NP_001396715.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 7
NM_013536.3 NP_038564.1 ribosomal RNA small subunit methyltransferase NEP1 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
20858271 MGI
acts upstream of or within nucleologenesis IMP
IMP: Inferred from mutant phenotype
20858271 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribosomal RNA small subunit methyltransferase NEP1

  • 18S rRNA (pseudouridine(1248)-N1)-methyltransferase

  • 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1

  • 18S rRNA Psi1248 methyltransferase

  • EMG1 nucleolar protein homolog

  • gene rich cluster, C2f

  • nucleolar protein EMG1 homolog

  • probable ribosome biogene

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04348 EMG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19595 Emg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26091 Emg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Emg1 NCBI NCBI:10436