NLRP4 - NLR family pyrin domain containing 4 Gene

Also Known as CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147945

About NLRP4

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:55,836,540-55,881,855 (from NCBI)

This gene has 4 transcripts (splice variants), 72 orthologues and 20 paralogues. Biased expression in testis (RPKM 3.5), lymph node (RPKM 0.8) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of Autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]

NLRP4 Products (1)

mRNA Protein Name
NM_134444.5 NP_604393.2 NACHT, LRR and PYD domains-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
27692986 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
27692986 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
27692986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRP4 Protein Structure

PYRIN

PYRIN: PAAD/DAPIN/Pyrin domain (8 - 89)

NACHT

NACHT: NACHT domain (149 - 317)

LRR_6

LRR_6: Leucine Rich repeat (806 - 829)

LRR_6

LRR_6: Leucine Rich repeat (863 - 885)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 994 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 4

  • NACHT, leucine rich repeat and PYD containing 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09360 NLRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NLRP4 RGD RGD:1563529
Macaca mulatta NLRP4 VGNC VGNC:75233
Others NLRP4 NCBI