Hsd17b8 - hydroxysteroid 17-beta dehydrogenase 8 Gene

Also Known as Ke6; Ke-6; Ring2; H-2Ke6; H2-Ke6; D17H6S112E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14979

Summary

Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within androgen metabolic process and estrogen metabolic process. Located in mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b8 Products (1)

mRNA Protein Name
NM_013543.2 NP_038571.2 (3R)-3-hydroxyacyl-CoA dehydrogenase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9712896 MGI
enables testosterone dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
9712896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within androgen metabolic process IDA
IDA: Inferred from direct assay
9712896 MGI
acts upstream of or within estrogen metabolic process IDA
IDA: Inferred from direct assay
9712896 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
8940387 MGI
located in mitochondrial envelope IDA
IDA: Inferred from direct assay
8940387 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8940387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

(3R)-3-hydroxyacyl-CoA dehydrogenase

  • 17-beta-HSD 8

  • 17-beta-hydroxysteroid dehydrogenase 8

  • 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit

  • 3-oxoacyl-[acyl-carrier-protein] reductase

  • H2-K region expressed gene 6

  • KAR alpha subunit

  • estradiol 17-beta-dehydrogenase 8

  • estrogen 17-o

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06400 HSD17B8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21239 Hsd17b8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27756 Hsd17b8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b8 NCBI NCBI:7923