Agfg1 - ArfGAP with FG repeats 1 Gene

Also Known as Hrb; RAB; Rip; C130049H11Rik; D730048C23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15463

Summary

Predicted to enable DNA binding activity; GTPase activator activity; and metal ion binding activity. Acts upstream of or within acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Located in cell projection; cytoplasmic vesicle; and neuronal cell body. Used to study male infertility. Orthologous to human AGFG1 (ArfGAP with FG repeats 1). [provided by Alliance of Genome Resources, Apr 2022]

Agfg1 Products (4)

mRNA Protein Name
NM_001310713.1 NP_001297642.1 arf-GAP domain and FG repeat-containing protein 1 isoform 2
NM_001347077.1 NP_001334006.1 arf-GAP domain and FG repeat-containing protein 1 isoform 3
NM_001368850.1 NP_001355779.1 arf-GAP domain and FG repeat-containing protein 1 isoform 4
NM_010472.3 NP_034602.1 arf-GAP domain and FG repeat-containing protein 1 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within acrosome assembly IMP
IMP: Inferred from mutant phenotype
11711676 MGI
acts upstream of or within intermediate filament organization IMP
IMP: Inferred from mutant phenotype
14724135 MGI
acts upstream of or within spermatid nucleus differentiation IMP
IMP: Inferred from mutant phenotype
16765935 MGI
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
16421295 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11711676 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16421295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arf-GAP domain and FG repeat-containing protein 1

  • HIV-1 Rev binding protein

  • HIV-1 Rev-binding protein homolog

  • arf-GAP domain and FG repeats-containing protein 1

  • nucleoporin-like protein RIP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00445 AGFG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22381 Agfg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28905 Agfg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agfg1 NCBI NCBI:3267