2. Gene
  3. CYP2A7 - cytochrome P450 family 2 subfamily A member 7 Gene

CYP2A7 - cytochrome P450 family 2 subfamily A member 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4

Gene ID: 1549 | Gene type: protein coding

About CYP2A7

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,875,439-40,882,231 (from NCBI)

This gene has 5 transcripts (splice variants), 119 orthologues and 15 paralogues. Restricted expression toward liver (RPKM 27.5).

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

CYP2A7 Products(2)

mRNA Protein Name
NM_000764.3 NP_000755.2 cytochrome P450 2A7 isoform 1 precursor
NM_030589.3 NP_085079.2 cytochrome P450 2A7 isoform 2 precursor

CYP2A7 Protein Structure

p450

p450: Cytochrome P450 (34 - 488)

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  • 494 a.a.
Protein Preferred Names Protein Names

cytochrome P450 2A7

cytochrome P450 IIA4

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03455 CYP2A7 Human Pre-designed siRNA Set A / Unkown
HY-RS03462 CYP2D7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYP2A7 RGD RGD:2465