Hspb1 - heat shock protein 1 Gene

Also Known as 27kDa; Hsp25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15507

Summary

Enables protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in Z disc; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hspb1 Products (1)

mRNA Protein Name
NM_013560.2 NP_038588.2 heat shock protein beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase C binding IDA
IDA: Inferred from direct assay
15731106 MGI
enables protein kinase C inhibitor activity IDA
IDA: Inferred from direct assay
15731106 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15731106 MGI
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15731106 MGI
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
15731106 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
12385642 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
12385642 MGI
involved in regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12385642 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
14627610 MGI
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
14627610 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11774370 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9122205 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11774370 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14627610 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock protein beta-1

  • HSP 25

  • HSP 27

  • growth-related 25 kDa protein

  • heat shock 25 kDa protein

  • heat shock 27 kDa protein

  • heat shock 27kDa protein 1

  • heat shock protein, 25 kDa

  • p25

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06438 HSPB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24382 Hspb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17913 Hspb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspb1 NCBI NCBI:3315