Abcg8 - ATP binding cassette subfamily G member 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 155192

Summary

Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and Cholesterol transfer activity. Involved in several processes, including bile acid signaling pathway; lipid homeostasis; and response to muscle activity. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcg8 Products (1)

mRNA Protein Name
NM_130414.2 NP_569098.2 ATP-binding cassette sub-family G member 8

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cholesterol homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15710224 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17109865 RGD
involved in triglyceride homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family G member 8

  • ATP-binding cassette, sub-family G (WHITE), member 8

  • ATP-binding cassette, subfamily G (WHITE), member 8

  • sterolin 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0288 Lycorine 99.98% Unkown
HY-N0288R Lycorine (Standard) 99.54% Unkown
HY-RS00082 ABCG8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181520 ABCA1 inducer 3 Inducer / Unkown
HY-RS18052 Abcg8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24526 Abcg8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcg8 NCBI NCBI:64241