PRAG1 - PEAK1 related, kinase-activating pseudokinase 1 Gene

Also Known as NACK; PEAK2; SGK223; PRAGMIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 157285

About PRAG1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:8,317,736-8,386,439 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 9.5), fat (RPKM 5.5) and 22 other tissues.

Summary

This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]

PRAG1 Products (2)

mRNA Protein Name
NM_001080826.3 NP_001074295.2 inactive tyrosine-protein kinase PRAG1
NM_001369759.1 NP_001356688.1 inactive tyrosine-protein kinase PRAG1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
29079850 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
29079850 GOA
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
27116701 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase PRAG1

  • PEAK family member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11047 PRAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRAG1 RGD RGD:1311793
Bos taurus PRAG1 VGNC VGNC:109385
Felis catus PRAG1 VGNC VGNC:109511
Macaca mulatta PRAG1 VGNC VGNC:109502
Mus musculus PRAG1 MGD MGI:1196223
Canis familiaris PRAG1 VGNC VGNC:59050