DAD1 - defender against cell death 1 Gene

Also Known as OST2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1603

About DAD1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,564,907-22,589,224 (from NCBI)

This gene has 5 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in thyroid (RPKM 108.7), adrenal (RPKM 94.4) and 25 other tissues.

Summary

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered Apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

DAD1 Products (1)

mRNA Protein Name
NM_001344.4 NP_001335.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
22467853 GOA
Biological Process GO Annotation Evidence References Source
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
31831667 GOA
involved in protein N-linked glycosylation via asparagine IMP
IMP: Inferred from mutant phenotype
22467853 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
22467853 GOA
Cellular Component GO Annotation Evidence References Source
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
22467853 GOA
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAD1 Protein Structure

DAD

DAD: DAD family (4 - 113)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

  • DAD-1

Related Diseases

Diseases Alias
Ogden Syndrome

  • OGDNS

  • N-Terminal Acetyltransferase Deficiency

  • NATD

  • N-Alpha-Acetyltransferase

  • X-Linked Malformation And Infantile Lethality Syndrome

  • Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03518 DAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DAD1 VGNC VGNC:27870
Felis catus DAD1 VGNC VGNC:61331
Rattus norvegicus DAD1 RGD RGD:621028
Mus musculus DAD1 MGD MGI:101912
Macaca mulatta DAD1 VGNC VGNC:71727
Others DAD1 NCBI