Itga5 - integrin alpha 5 (fibronectin receptor alpha) Gene

Also Known as Fnra; VLA5; Cd49e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16402

Summary

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the Integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and Integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Itga5 Products (2)

mRNA Protein Name
NM_001314041.1 NP_001300970.1 integrin alpha-5 isoform 2
NM_010577.4 NP_034707.5 integrin alpha-5 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
8601592 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12867986 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
36812915 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within cell-substrate junction assembly IDA
IDA: Inferred from direct assay
12867986 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
12904471 MGI
involved in regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
19460962 MGI
involved in response to muscle activity IDA
IDA: Inferred from direct assay
36812915 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12189152 MGI
located in cell surface IDA
IDA: Inferred from direct assay
8306881 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12189152 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12189152 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8557754 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
36812915 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12189152 MGI
located in synapse IDA
IDA: Inferred from direct assay
12904471 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-5

  • CD49 antigen-like family member E

  • fibronectin receptor alpha polypeptide

  • fibronectin receptor subunit alpha

  • integrin alpha-F

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06952 ITGA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16901 Itga5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23343 Itga5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga5 NCBI NCBI:3678