Itgav - integrin alpha V Gene

Also Known as CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16410

Summary

This gene encodes a protein that is a member of the Integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]

Itgav Products (2)

mRNA	Protein	Name
NM_001398691.1	NP_001385620.1	integrin alpha-V isoform 2 precursor
NM_008402.4	NP_032428.2	integrin alpha-V isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	20826760	MGI
contributes to opsonin binding	IDA IDA: Inferred from direct assay	20826760	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	38016540	MGI
contributes to protein kinase C binding	IDA IDA: Inferred from direct assay	16014375	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16014375	MGI
involved in apoptotic cell clearance	IDA IDA: Inferred from direct assay	20826760	MGI
involved in apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	20826760	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15647754	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12370313	MGI
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	24681597	MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	15591537	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20675382	MGI
involved in positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	20675382	MGI
involved in transforming growth factor beta production	IDA IDA: Inferred from direct assay	24681597	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8557754	MGI
part of integrin alphav-beta5 complex	IDA IDA: Inferred from direct assay	20826760	MGI
part of integrin alphav-beta6 complex	IDA IDA: Inferred from direct assay	24681597	MGI
located in membrane	IDA IDA: Inferred from direct assay	20151413	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14566019	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
integrin alpha-V	alpha v integrin vitronectin receptor alpha polypeptide (VNRA) vitronectin receptor subunit alpha

Recombinant Itgav Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77723	Integrin alpha V beta 6 Protein, Mouse (HEK293, His)	P43406 (F31-V988)&Q9Z0T9 (G22-N706)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06961	ITGAV Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16754	Itgav Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23193	Itgav Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990667B	STX-100 (Biotinylated)	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgav	NCBI	NCBI:3685