Kif7 - kinesin family member 7 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16576

Summary

Enables identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and positive regulation of smoothened signaling pathway. Acts upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Located in ciliary basal body. Is expressed in metanephros and testis. Used to study acrocallosal syndrome; ciliopathy; congenital diaphragmatic hernia; and hydrolethalus syndrome. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (Kinesin family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Kif7 Products (4)

mRNA Protein Name
NM_001291222.2 NP_001278151.1 kinesin-like protein KIF7 isoform 1
NM_001412613.1 NP_001399542.1 kinesin-like protein KIF7 isoform 3
NM_001412614.1 NP_001399543.1 kinesin-like protein KIF7 isoform 4
NM_010626.3 NP_034756.2 kinesin-like protein KIF7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
24952464 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19549984 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19549984 MGI
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19549984 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
25644602 MGI
located in ciliary tip IDA
IDA: Inferred from direct assay
29038301 MGI
located in cilium IDA
IDA: Inferred from direct assay
19666503 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin-like protein KIF7

  • kinesin 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07295 KIF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22213 Kif7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28735 Kif7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif7 NCBI NCBI:374654