Krt19 - keratin 19 Gene

Also Known as K19; CK-19; EndoC; Krt1-19; Krt-1.19

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16669

Summary

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Krt19 Products (2)

mRNA Protein Name
NM_001313963.1 NP_001300892.1 keratin, type I cytoskeletal 19 isoform 2
NM_008471.3 NP_032497.1 keratin, type I cytoskeletal 19 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19321664 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within cell differentiation involved in embryonic placenta development IGI
IGI: Inferred from genetic interaction
11062258 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15247274 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
25232867 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
15247274 MGI
located in terminal web IDA
IDA: Inferred from direct assay
19321664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 19

  • cytokeratin 19

  • keratin complex 1, acidic, gene 19

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-RS07442 KRT19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16276 Krt19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25946 Krt19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt19 NCBI NCBI:3880