DEFA4 - defensin alpha 4 Gene

Also Known as HP4; DEF4; HP-4; HNP-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1669

About DEFA4

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,935,820-6,938,306 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 165 orthologues and 5 paralogues. Restricted expression toward bone marrow (RPKM 1355.2).

Summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from Other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

DEFA4 Products (1)

mRNA Protein Name
NM_001925.3 NP_001916.1 defensin alpha 4 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17088326 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell chemotaxis IDA
IDA: Inferred from direct assay
17088326 GOA
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
2500436 GOA
involved in antifungal humoral response IDA
IDA: Inferred from direct assay
2500436 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
2500436 GOA
involved in antimicrobial humoral response IDA
IDA: Inferred from direct assay
2500436 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
2500436 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
2500436 GOA
involved in defense response to fungus IDA
IDA: Inferred from direct assay
2500436 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
2500436 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
15616305 GOA
Cellular Component GO Annotation Evidence References Source
located in azurophil granule IDA
IDA: Inferred from direct assay
2500436 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEFA4 Protein Structure

Defensin_propep

Defensin_propep: Defensin propeptide (1 - 52)

Defensin_1

Defensin_1: Mammalian defensin (65 - 93)

  • 0
  • 97 a.a.
Protein Preferred Names Protein Names

defensin alpha 4

  • corticostatin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03675 DEFA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DEFA4 RGD RGD:727857