Psmb8 - proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Gene

Also Known as Lmp7; Lmp-7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16913

Summary

Predicted to enable endopeptidase activity. Involved in fat cell differentiation. Acts upstream of or within antigen processing and presentation. Part of Proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (Proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]

Psmb8 Products (1)

mRNA Protein Name
NM_010724.2 NP_034854.2 proteasome subunit beta type-8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31915251 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
15356141 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
21881205 MGI
Cellular Component GO Annotation Evidence References Source
part of proteasome core complex IDA
IDA: Inferred from direct assay
16857966 MGI
part of spermatoproteasome complex IDA
IDA: Inferred from direct assay
23706739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteasome subunit beta type-8

  • MC13 (LMP7)

  • large multifunctional protease 7

  • low molecular mass protein 7

  • macropain subunit C13

  • multicatalytic endopeptidase complex subunit C13

  • proteasome component C13

  • proteasome subunit MC13

  • proteasome subunit beta-5i

  • proteosome (prosome, macro

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20471 Psmb8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170881 TIR-199 Inhibitor / Unkown
HY-RS11308 PSMB8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26979 Psmb8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psmb8 NCBI NCBI:5696