Lrp5 - low density lipoprotein receptor-related protein 5 Gene

Also Known as HBM; LR3; LRP7; OPPG; BMND1; mKIAA4142

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16973

Summary

Enables Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of osteoblast differentiation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Lrp5 Products (1)

mRNA Protein Name
NM_008513.3 NP_032539.2 low-density lipoprotein receptor-related protein 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
11956231 MGI
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
11956231 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18632848 MGI
Biological Process GO Annotation Evidence References Source
involved in Norrin signaling pathway IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22272305 MGI
acts upstream of or within amino acid transport IMP
IMP: Inferred from mutant phenotype
22272305 MGI
acts upstream of or within anatomical structure regression IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
22272305 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
17700537 MGI
acts upstream of or within bone remodeling IGI
IGI: Inferred from genetic interaction
15537447 MGI
acts upstream of or within bone remodeling IMP
IMP: Inferred from mutant phenotype
11956231 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
16973609 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
11956231 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
15923619 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16973609 MGI
acts upstream of or within cell migration involved in gastrulation IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
22272305 MGI
acts upstream of or within cell-cell signaling involved in mammary gland development IMP
IMP: Inferred from mutant phenotype
16973609 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
12509515 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within establishment of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
25083995 MGI
acts upstream of or within establishment of blood-retinal barrier IMP
IMP: Inferred from mutant phenotype
25083995 MGI
involved in extracellular matrix-cell signaling IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within gastrulation with mouth forming second IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
22272305 MGI
acts upstream of or within limb morphogenesis IGI
IGI: Inferred from genetic interaction
15537447 MGI
acts upstream of or within mammary gland duct morphogenesis IGI
IGI: Inferred from genetic interaction
19503830 MGI
acts upstream of or within mesodermal cell migration IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within osteoblast development IMP
IMP: Inferred from mutant phenotype
16790443 MGI
involved in osteoblast development IMP
IMP: Inferred from mutant phenotype
17700537 MGI
acts upstream of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
11956231 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15035989 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15035989 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
26891291 MGI
acts upstream of or within positive regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
11956231 MGI
NOT involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
18957220 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11956231 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
12509515 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: Inferred from mutant phenotype
22272305 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IGI
IGI: Inferred from genetic interaction
19837032 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
11956231 MGI
involved in retinal blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
27031698 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19672307 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
16163358 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 5

  • LRP-5

  • LRP-7

  • low-density lipoprotein receptor-related protein 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125146 BMD4503-2 99.21% Unkown
HY-RS16292 Lrp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181585 FP1-24 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-RS07800 LRP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169508 BMD4503-1 Modulator / Unkown
HY-RS24282 Lrp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992126 Remigromig Inhibitor / Unkown
HY-P991569 PF-04840082 Antagonist / Unkown
HY-P992263 Anti-LRP5 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp5 NCBI NCBI:4041