Gcsh - glycine cleavage system protein H Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171133

Summary

Enables aminomethyltransferase activity and enzyme binding activity. Involved in glycine decarboxylation via glycine cleavage system. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Apr 2022]

Gcsh Products (1)

mRNA Protein Name
NM_133598.2 NP_598282.2 glycine cleavage system H protein, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aminomethyltransferase activity IMP
IMP: Inferred from mutant phenotype
6402507 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
6778858 RGD
Biological Process GO Annotation Evidence References Source
involved in glycine decarboxylation via glycine cleavage system IMP
IMP: Inferred from mutant phenotype
6402507 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycine cleavage system H protein, mitochondrial

  • glycine cleavage system protein H (aminomethyl carrier)

  • lipoic acid-containing protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05344 GCSH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19334 Gcsh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25825 Gcsh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcsh NCBI NCBI:2653