Ehhadh - enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Gene

Also Known as Lbp; MEF; Mfe; Pbe; MFP1; Mfe1; Pbfe; pe-CoA; perMFE-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171142

Summary

Enables several functions, including 3-hydroxyacyl-CoA dehydrogenase activity; dodecenoyl-CoA delta-isomerase activity; and enoyl-CoA hydratase activity. Involved in fatty acid beta-oxidation. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Orthologous to human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Ehhadh Products (1)

mRNA Protein Name
NM_133606.2 NP_598290.1 peroxisomal bifunctional enzyme

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
IDA: Inferred from direct assay
4019459 RGD
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
IDA: Inferred from direct assay
11781327 RGD
enables enoyl-CoA hydratase activity IDA
IDA: Inferred from direct assay
12106015 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
16781659 RGD
enables intramolecular oxidoreductase activity, transposing C=C bonds IDA
IDA: Inferred from direct assay
11781327 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid beta-oxidation IDA
IDA: Inferred from direct assay
11781327 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16781659 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
11781327 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisomal bifunctional enzyme

  • L-specific bifunctional protein

  • enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

  • enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

  • multifunctional enzyme 1

  • multifunctional enzyme type 1

  • multifunctional protein 1

  • peroxisomal bifu

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04226 EHHADH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18562 Ehhadh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25044 Ehhadh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehhadh NCBI NCBI:1962