PTCRA - pre T cell antigen receptor alpha Gene

Homo sapiens

Also known as PTA; PT-ALPHA

Gene ID: 171558 | Gene type: protein coding

About PTCRA

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,916,053-42,925,838 (from NCBI)

This gene has 4 transcripts (splice variants) and 84 orthologues. Biased expression in spleen (RPKM 1.2), lymph node (RPKM 0.8) and 5 other tissues.

Summary

The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PTCRA Products(4)

mRNA	Protein	Name
NM_001243168.2	NP_001230097.1	pre T-cell antigen receptor alpha isoform 1 precursor
NM_001243169.2	NP_001230098.1	pre T-cell antigen receptor alpha isoform 3 precursor
NM_001243170.2	NP_001230099.1	pre T-cell antigen receptor alpha isoform 4 precursor
NM_138296.3	NP_612153.2	pre T-cell antigen receptor alpha isoform 2 precursor

PTCRA Protein Structure

PTCRA

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

pre T-cell antigen receptor alpha

pT-alpha-TCR

Related Diseases

Diseases

Alias

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11360	PTCRA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTCRA	VGNC	VGNC:64426
Bos taurus	PTCRA	VGNC	VGNC:33494
Macaca mulatta	PTCRA	VGNC	VGNC:76298
Canis familiaris	PTCRA	VGNC	VGNC:54346
Rattus norvegicus	PTCRA	RGD	RGD:621388
Mus musculus	PTCRA	MGD	MGI:104857

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