PTCRA - pre T cell antigen receptor alpha Gene

Also Known as PTA; PT-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 171558

About PTCRA

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,916,053-42,925,838 (from NCBI)

This gene has 4 transcripts (splice variants) and 84 orthologues. Biased expression in spleen (RPKM 1.2), lymph node (RPKM 0.8) and 5 other tissues.

Summary

The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PTCRA Products (4)

mRNA	Protein	Name
NM_001243168.2	NP_001230097.1	pre T-cell antigen receptor alpha isoform 1 precursor
NM_001243169.2	NP_001230098.1	pre T-cell antigen receptor alpha isoform 3 precursor
NM_001243170.2	NP_001230099.1	pre T-cell antigen receptor alpha isoform 4 precursor
NM_138296.3	NP_612153.2	pre T-cell antigen receptor alpha isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22795130	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTCRA Protein Structure

PTCRA

0
100
200
281 a.a.

Protein Preferred Names	Protein Names
pre T-cell antigen receptor alpha	pT-alpha-TCR

Related Diseases

Diseases	Alias
Immunodeficiency 19	IMD19 Cd3-Delta Deficiency Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Cd3delta Deficiency Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Immunodeficiency 19, Severe Combined Cd3d Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency Immunodeficiency, Type 19
Immunodeficiency 18	IMD18 Cd3-Epsilon Deficiency Immunodeficiency 18, Scid Variant Cd3epsilon Deficiency Immunodeficiency 18, Severe Combined Immunodeficiency Variant Immunodeficiency, Type 18
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11360	PTCRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22752	Ptcra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29266	Ptcra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTCRA	VGNC	VGNC:64426
Bos taurus	PTCRA	VGNC	VGNC:33494
Macaca mulatta	PTCRA	VGNC	VGNC:76298
Canis familiaris	PTCRA	VGNC	VGNC:54346
Rattus norvegicus	PTCRA	RGD	RGD:621388
Mus musculus	PTCRA	MGD	MGI:104857
Others	PTCRA	NCBI