Nprl3 - nitrogen permease regulator-like 3 Gene

Also Known as Aag; Phg; Mare; HS-26; HS-40; Prox1; CGTHBA; m(alpha)RE

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17168

Summary

Predicted to contribute to GTPase activator activity. Acts upstream of or within circulatory system development and roof of mouth development. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Nprl3 Products (3)

mRNA Protein Name
NM_001284359.1 NP_001271288.1 GATOR complex protein NPRL3 isoform 1
NM_001284360.1 NP_001271289.1 GATOR complex protein NPRL3 isoform 3
NM_181569.3 NP_853547.1 GATOR complex protein NPRL3 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
22538705 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
22538705 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
22538705 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
22538705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GATOR complex protein NPRL3

  • -14

  • alpha globin regulatory element containing

  • alpha-globin regulatory element-containing gene protein

  • nitrogen permease regulator 3-like protein

  • proximal locus to the hemoglobin alpha chain complex

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09501 NPRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20455 Nprl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26964 Nprl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nprl3 NCBI NCBI:8131