Ascl1 - achaete-scute family bHLH transcription factor 1 Gene

Also Known as ASH1; Mash1; bHLHa46

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17172

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in nervous system development. Acts upstream of or within several processes, including musculoskeletal movement, spinal reflex action; nervous system development; and neuroendocrine cell differentiation. Located in neuronal cell body and nucleus. Is expressed in several structures, including future brain; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ascl1 Products (1)

mRNA Protein Name
NM_008553.5 NP_032579.2 achaete-scute homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17141158 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
23639443 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23639443 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17141158 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within GABAergic neuron differentiation IGI
IGI: Inferred from genetic interaction
15071116 MGI
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
11073877 MGI
acts upstream of or within adrenal chromaffin cell differentiation IMP
IMP: Inferred from mutant phenotype
12361965 MGI
acts upstream of or within carotid body glomus cell differentiation IMP
IMP: Inferred from mutant phenotype
15878769 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
16766700 MGI
acts upstream of or within central nervous system neuron development IGI
IGI: Inferred from genetic interaction
15169849 MGI
acts upstream of or within central nervous system neuron development IMP
IMP: Inferred from mutant phenotype
16469766 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
17678855 MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain IMP
IMP: Inferred from mutant phenotype
22991444 MGI
acts upstream of or within generation of neurons IMP
IMP: Inferred from mutant phenotype
23616538 MGI
acts upstream of or within lung neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
9126746 MGI
acts upstream of or within motor neuron migration IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
15976074 MGI
acts upstream of or within musculoskeletal movement, spinal reflex action IMP
IMP: Inferred from mutant phenotype
23616538 MGI
involved in nervous system development IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
21536733 MGI
acts upstream of or within neuroblast fate determination IMP
IMP: Inferred from mutant phenotype
11032813 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of or within neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
10952889 MGI
involved in neuron development IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
9108377 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
18184563 MGI
involved in neuron differentiation IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
15133515 MGI
involved in neuron fate commitment IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
16020526 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
12629181 MGI
involved in neuron fate specification IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
16469766 MGI
involved in noradrenergic neuron development IMP
IMP: Inferred from mutant phenotype
18094025 MGI
acts upstream of or within olfactory pit development IMP
IMP: Inferred from mutant phenotype
9108377 MGI
acts upstream of or within oligodendrocyte cell fate commitment IMP
IMP: Inferred from mutant phenotype
17678855 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
18287202 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15976074 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18287202 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
15930101 MGI
acts upstream of or within peripheral nervous system neuron development IMP
IMP: Inferred from mutant phenotype
8845150 MGI
acts upstream of or within positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
11073877 MGI
acts upstream of or within positive regulation of cell cycle IDA
IDA: Inferred from direct assay
21536733 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
21536733 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16469766 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16469766 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17141158 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
8900141 MGI
acts upstream of or within regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
19191219 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19793887 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
23284756 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16469766 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18094025 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22991444 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20144606 MGI
acts upstream of or within regulation of timing of subpallium neuron differentiation IMP
IMP: Inferred from mutant phenotype
9876181 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24243019 MGI
acts upstream of or within spinal cord association neuron differentiation IMP
IMP: Inferred from mutant phenotype
16715081 MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation IGI
IGI: Inferred from genetic interaction
18287202 MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification IMP
IMP: Inferred from mutant phenotype
18287202 MGI
acts upstream of or within stomach neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
18173746 MGI
acts upstream of or within subpallium neuron fate commitment IMP
IMP: Inferred from mutant phenotype
9876181 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
18094025 MGI
involved in ventral spinal cord interneuron fate commitment IMP
IMP: Inferred from mutant phenotype
16020526 MGI
acts upstream of or within vestibular nucleus development IMP
IMP: Inferred from mutant phenotype
12885554 MGI
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
11133151 MGI
located in nucleus IDA
IDA: Inferred from direct assay
1576967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

achaete-scute homolog 1

  • achaete-scute complex homolog-like 1

  • achaete-scute complex-like protein 1

  • mammalian achaete scute homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155218 TMX-2172 Degrader 99.38% Unkown
HY-RS01078 ASCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174778 Human ASCL1 mRNA / Unkown
HY-RS21486 Ascl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28004 Ascl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991871 Anti-ASCL1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ascl1 NCBI NCBI:429