Meox1 - mesenchyme homeobox 1 Gene

Also Known as Mox1; Mox-1; D330041M02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17285

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in sclerotome development. Acts upstream of or within positive regulation of transcription by RNA polymerase II and somite specification. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Meox1 Products (1)

mRNA Protein Name
NM_010791.3 NP_034921.1 homeobox protein MOX-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15024065 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15024065 MGI
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15024065 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15024065 MGI
enables sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
22206000 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15024065 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15024065 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15024065 MGI
involved in sclerotome development IMP
IMP: Inferred from mutant phenotype
15024065 MGI
involved in somite development IMP
IMP: Inferred from mutant phenotype
19520072 MGI
acts upstream of or within somite specification IGI
IGI: Inferred from genetic interaction
12925591 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22206000 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22206000 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein MOX-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134462 RJW103 Agonist 98.71% Unkown
HY-RS08334 MEOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20445 Meox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26954 Meox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meox1 NCBI NCBI:4222