Pias2 - protein inhibitor of activated STAT 2 Gene

Also Known as DIP; Dib; Miz1; SIZ2; ARIP3; PIASxb; PIASxbeta; PIASxalpha; PIASxalpha6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17344

Summary

Enables DNA binding activity; SUMO transferase activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including protein sumoylation; regulation of osteoblast differentiation; and transcription, DNA-templated. Located in nuclear body. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]

Pias2 Products (5)

mRNA Protein Name
NM_001164167.1 NP_001157639.1 E3 SUMO-protein ligase PIAS2 isoform 2
NM_001164168.1 NP_001157640.1 E3 SUMO-protein ligase PIAS2 isoform 3
NM_001164169.1 NP_001157641.1 E3 SUMO-protein ligase PIAS2 isoform 4
NM_001164170.1 NP_001157642.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_008602.4 NP_032628.3 E3 SUMO-protein ligase PIAS2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9256341 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20408817 MGI
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
15123625 MGI
enables SUMO transferase activity IDA
IDA: Inferred from direct assay
15767674 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11104669 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16816390 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA-templated transcription IDA
IDA: Inferred from direct assay
9256341 MGI
acts upstream of or within protein sumoylation IDA
IDA: Inferred from direct assay
15767674 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9256341 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16522640 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS2

  • DAB2-interacting protein

  • Msx-interacting-zinc finger

  • RING-type E3 ubiquitin transferase PIAS2

  • androgen receptor-interacting protein 3

  • msx-interacting zinc finger protein

  • protein inhibitor of activated STAT x

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10474 PIAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22729 Pias2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias2 NCBI NCBI:9063