Mllt10 - myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 Gene

Also Known as Af10; mKIAA4140; B130021D15Rik; D630001B22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17354

Summary

Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]

Mllt10 Products (3)

mRNA Protein Name
NM_001252560.1 NP_001239489.1 protein AF-10 isoform 1
NM_001252561.1 NP_001239490.1 protein AF-10 isoform 2
NM_010804.4 NP_034934.2 protein AF-10 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21103407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein AF-10

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

  • translocated to, 10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08494 MLLT10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21886 Mllt10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28403 Mllt10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mllt10 NCBI NCBI:8028