Msh6 - mutS homolog 6 Gene

Also Known as GTBP; Gtmbp

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17688

Summary

Enables chromatin binding activity; damaged DNA binding activity; and guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal Cancer type 5; and mismatch repair Cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2022]

Msh6 Products (1)

mRNA	Protein	Name
NM_010830.2	NP_034960.1	DNA mismatch repair protein Msh6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IGI IGI: Inferred from genetic interaction	10545954	MGI
enables DNA binding	IMP IMP: Inferred from mutant phenotype	10545954	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16618598	MGI
enables damaged DNA binding	IGI IGI: Inferred from genetic interaction	10545954	MGI
enables damaged DNA binding	IMP IMP: Inferred from mutant phenotype	10545954	MGI
contributes to guanine/thymine mispair binding	IDA IDA: Inferred from direct assay	16713580	MGI
enables guanine/thymine mispair binding	IDA IDA: Inferred from direct assay	15324697	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	9390556	MGI
acts upstream of or within intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14632208	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	15324697	MGI
acts upstream of or within isotype switching	IGI IGI: Inferred from genetic interaction	17015724	MGI
acts upstream of or within isotype switching	IMP IMP: Inferred from mutant phenotype	16618598	MGI
acts upstream of or within mismatch repair	IGI IGI: Inferred from genetic interaction	11691815	MGI
acts upstream of or within mismatch repair	IMP IMP: Inferred from mutant phenotype	9390556	MGI
acts upstream of or within negative regulation of DNA recombination	IMP IMP: Inferred from mutant phenotype	10545954	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	14632208	MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes	IMP IMP: Inferred from mutant phenotype	10662804	MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments	IMP IMP: Inferred from mutant phenotype	15238604	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of MutSalpha complex	IDA IDA: Inferred from direct assay	16713580	MGI
located in chromatin	IDA IDA: Inferred from direct assay	16618598	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA mismatch repair protein Msh6	g/T mismatch-binding protein mutS protein homolog 6 mutS-alpha 160 kDa subunit p160

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08713	MSH6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22241	Msh6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28763	Msh6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Msh6	NCBI	NCBI:2956